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What is the Tretinoin ?
Tretinoin is yellow-orange powder, while it's Molecular Formula is C20H28O2. retinoic acid (tretinoin) is a vitamin A derivative. It has demonstrated an ability to alter collagen synthesis, increase dermal hyaluronic acid levels, and stimulate fibroblast growth and the extracellular matrix. It is used for keratinization disorders and for treating acne. Retinoic acid’s anti-aging effect has been convincingly documented and it is often used for treating the visible signs of aging, though these results can take approximately 6 months to be visible. It is associated with a number of adverse effects, including irritation, photosensitivity, skin dryness, redness, and peeling. It should also not be used while pregnant.
What is the CAS number for Tretinoin ?
The CAS number of Tretinoin is 302-79-4.
More information of Tretinoin 302-79-4 are:
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Synonyms
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(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoate;all-trans-beta-Retinoic acid;Vitamin A acid;Tretinoine (French) (EINECS);Retin A;trans-Retinoic acid;all-trans-Vitamin A1 acid;Acide retinoique (French) (DSL);2,4, 6,8-Nonatetranoic acid, 3,7-dimethyl-9-(2,6, 6-trimethyl-1-cyclohexen-1-yl)-, (2E, 4E, 6E, 8E)-;all-trans-Retinoate;AGN 100335;Vitamin A acid sodium salt;Vitamin A1 acid, all-trans-;ATRA;Retin-A;Vesnaroid;Tretin M;all-(E)-Retinoic acid;Retinoic acid, sodium salt;beta-Retinoic acid;Cordes Vas;Aberel;Tretinoin, all-trans-;Retionic acid;Dermairol;Eudyna;Aknefug;Retinoate;all-trans-Retinoic acid;Retacnyl;Tretinoin (all-trans retinoic acid );Tretinoin USP26; |
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CAS Number
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302-79-4 |
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Molecular Formula
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C20H28O2 |
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Molecular Weight
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300.441 |
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Density
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1.011 g/cm3 |
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Melting Point
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179-184 °C |
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Boiling Point
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462.8 °C at 760 mmHg |
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Flash Point
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350.6 °C |
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HS CODE
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29362100 |
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PSA
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37.30000 |
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LogP
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5.60260 |
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Pka
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4.73±0.33(Predicted) |
What is Tretinoin (302-79-4) used for?
all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; ) in mice. It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis. all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.
InChI:InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+
Articles related to Tretinoin:
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Article
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Source
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A new one-pot synthesis of all E-retinoic acid via a new enaminodiester synthon
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Cartier, Dominique,Valla, Alain,Labia, Roger,Le Guillou, Régis,Potier, Pierre
, p. 5789 - 5790 (2003)
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Design, synthesis, and ex vivo evaluation of a selective inhibitor for retinaldehyde dehydrogenase enzymes
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Harper, Angelica R.,Le, Anh T.,Mather, Timothy,Burgett, Anthony,Berry, William,Summers, Jody A.
, p. 5766 - 5779 (2018)
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How to get the best price on Tretinoin?
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