Reputable manufacturer supply AMFONELIC ACID 15180-02-6 in stock with high standard
- Molecular Formula:C18H16N2O3
- Molecular Weight:308.33
- Appearance/Colour:yellow powder
- Vapor Pressure:8.66E-11mmHg at 25°C
- Melting Point:>1000 °C
- Refractive Index:1.63
- Boiling Point:499.308 °C at 760 mmHg
- PKA:3.50±0.20(Predicted)
- Flash Point:255.772 °C
- PSA：72.19000
- Density:1.298 g/cm3
- LogP:2.70540
AMFONELIC ACID(Cas 15180-02-6) Usage
| Description |
Amfonelic acid (AFA) is a non-amphetamine stimulant and research chemical that affects brain dopamine metabolism. Jilin Tianyun New Materials Co., Ltd. is a professional production enterprise that production, processing, and export, mainly engaged in various organic chemicals. The company has a wealth of professional experience, reliable product quality, reasonable prices, and products are exported to countries around the world, which can meet your diverse needs. In our business cooperation with clients, we always adhere to the principle of equality and mutual benefit, and are deeply trusted and recognized by our clients. If you are interested in our company and our products, please feel free to visit our website or contact us directly for more information.We look forward to establishing a long-term stable and win-win business relationship with you. |
| Uses |
Amfonelic acid is a dopamine reuptake inhibitor that can be used to study the brain's dopamine pathway and dopamine transporter. It can lower the threshold for rewarding brain stimulation delivered to the medial forebrain bundle-lateral hypothalamus. |
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Pharmacokinetics
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Amfonelic acid, a derivative of nalidixic acid, was originally developed as a central nervous system stimulant. It is a highly potent nonamphetamine stimulant whose actions are inhibited by reserpine but not by the tyrosine hydroxylase inhibitor, a-methyltyrosine.
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| Reference |
Here, we report a practical synthesis of diversely functionalized 1,8-naphthyridone-3-carboxylic acid derivatives starting from readily available and inexpensive nicotinic acid derivatives. All key steps have been optimized. Furthermore, the usefulness of this protocol has been exemplified by the first synthesis of amfonelic acid.
, Kaijuan WangChengcheng GongWeiwei XiaoAblimit AbdukaderDong Wang*
, J. Org. Chem. 2024, 89, 8, 5811–5824
, Accessing 1,8-Naphthyridone-3-carboxylic Acid Derivatives and Application to the Synthesis of Amfonelic Acid
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InChI:InChI=1/C18H16N2O3/c1-2-20-11-15(18(22)23)16(21)14-9-8-13(19-17(14)20)10-12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,22,23)
