What is the Chlorhexidine digluconate?

Chlorhexidine digluconate is An almost colourless or pale - yellowish liquid, miscible with water,, while it's Molecular Formula is C34H54Cl2N10O14 . An almost colourless or pale - yellowish liquid, miscible with water, Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.Chlorhexidine digluconate 20% solution is a broad spectrum bacteriostatis antiseptic agent, oral care agent, disinfectant, cosmetic biocide, and preservative. It is very effective against plaque, oral flora including Candida and is active against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast. It can be used in antiseptic soap, mouthwash that fights plaque, disinfecting wounds and burns, vaginal flushing, hair dyes and bleaches, makeup, and other skin and hair care products.

What is the CAS number for Chlorhexidine digluconate?

The CAS number of Chlorhexidine digluconate is 18472-51-0.

What is Chlorhexidine digluconate (18472-51-0) used for?

Chlorhexidine digluconate solution is a bis(biguanide) family cationic broad spectrum antibiotic that is available in a range of concentrations and has been safely used for over 40 years for a variety of health-related applications; but its specific use for umbilical cord care was uniquely tested in three clinical trials in Nepal, Bangladesh, and Pakistan, in the form of 7.1% chlorhexidine digluconate (CHX). Given the promising results of the trials, in 2013 the World Health Organization (WHO) added CHX to its Model List of Essential Medicines for Children; and in 2014 the WHO issued a new guideline on umbilical cord care, which included a formal recommendation on the use of chlorhexidine.Chlorhexidine digluconate is a broad spectrum antiseptic. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.It has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.It is also useful against fungi and enveloped viruses, though this has not been extensively investigated. Chlorhexidine is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions.InChI:InChI=1/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)

Manufacturer supply Chlorhexidine digluconate 18472-51-0 with sufficient stock and high standard

Product Details;

CasNo： 18472-51-0

Molecular Formula： C₃₄H₅₄Cl₂N₁₀O₁₄

Appearance： An almost colourless or pale - yellowish liquid, miscible with water,

Manufacturer supply Chlorhexidine digluconate 18472-51-0 with sufficient stock and high standard

Molecular Formula:C34H54Cl2N10O14
Molecular Weight:897.767
Appearance/Colour:An almost colourless or pale - yellowish liquid, miscible with water,
Vapor Pressure:0mmHg at 25°C
Melting Point:134 °C
Boiling Point:699.3 °C at 760 mmHg
Flash Point:376.7 °C
PSA：444.48000
Density:1.06 g/mL at 25 °C(lit.)
LogP:-0.70240

Chlorhexidine digluconate(Cas 18472-51-0) Usage

Manufacturing Process	35 parts of hexamethylene bis-dicyandiamide, 35 parts of p-chloroaniline hydrochloride and 250 parts of β-etoxyethanol are stirred together at 130- 140°C for 2 hours under reflux. The mixture is then cooled and filtered. The solid is washed with water and crystallised from 50% aqueous acetic acid. 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) is obtained as colorless plates, melting point 258-260°C. By addition of D-gluconic acid to aqueous solution of chlorhexidine base is prepared 1,1'-hexamethylenebis(5-(pchlorophenyl)biguanide)digluconate (1:2).
Brand name	Dyna-Hex (Xttrium); Hibiclens (Regent); Peridex (Zila); Periochip (Dexcel); Periogard (Colgate); Prevacare (Johnson & Johnson).
General Description	Chlorhexidine is a cationic biguanide and was first described in 1954 as a promising new antibacterial agent, at that time as a diacetate and dihydrochloride. Chlorhexidine gluconate is an antiseptic agent that has been shown to decrease microbial flora on the skin and prevent infection risk in various settings, including as a skin preparatory agent for surgical procedures and for insertion of vascular access devices, as a surgical hand scrub, and for oral hygiene.
Uses	Chlorhexidine gluconate mouthwash can be used to treat gingivitis, a bacterial gum disease that causes red, swollen, and bleeding gums. It works by reducing the amount of bacteria in the mouth, which helps to reduce inflammation and bleeding. However, it's not a substitute for regular brushing and flossing. Chlorhexidine gluconate can help inhibit the adherence of microorganisms to surfaces, which prevents the growth and development of biofilms.
Biochem/physiol Actions	Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
Manufacturer	Jilin Tianyun New Materials Co., Ltd. is a professional production enterprise that production, processing, and export, mainly engaged in various organic chemicals. The company has a wealth of professional experience, reliable product quality, reasonable prices, and products are exported to countries around the world, which can meet your diverse needs. In our business cooperation with clients, we always adhere to the principle of equality and mutual benefit, and are deeply trusted and recognized by our clients. If you are interested in our company and our products, please feel free to visit our website or contact us directly for more information.We look forward to establishing a long-term stable and win-win business relationship with you.
Reference	Although several studies have shown that chlorhexidine digluconate (CHX) has bactericidal activity against periodontal pathogens and exerts toxic effects on periodontal tissues, few have been directed to evaluate the mechanisms underlying its adverse effects on these tissues. Therefore, the aim of the present study was to investigate the in vitro cytotoxicity of CHX on cells that could represent common targets for its action in the surgical procedures for the treatment of periodontitis and peri-implantitis and to elucidate its mechanisms of action. , Toxicology in Vitro Volume 22, Issue 2 , March 2008, Pages 308-317 , Effect of chlorhexidine digluconate on different cell types: A molecular and ultrastructural investigation

InChI:InChI=1/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)

18472-51-0 Downstream products

89697-78-9
chlorhexidine orthophosphate

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