Tacrolimus(Cas 104987-11-3) Usage
Tacrolimus, a powerful immunosuppressant, is often used to prevent rejection after organ transplantation, especially in liver, kidney and heart transplantation. It reduces the attack on transplanted organs by suppressing the activity of the immune system. At the same time, tacrolimus is also used to treat certain autoimmune diseases, such as atopic dermatitis. Tacrolimus is generally obtained by chemical synthesis, and blood drug concentrations need to be strictly monitored during use to ensure efficacy and safety.
InChI:InChI=1/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19-,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
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104987-11-3 Relevant articles
Tacrolimus: a review of its use for the management of dermatoses
AK Gupta, A Adamiak, M Chow
, Journal of the European Academy of Dermatology and Venereology, Volume16, Issue2 March 2002 Pages 100-114
There is limited systemic absorption of tacrolimus over the course of therapy. The most extensive experience with tacrolimus has been in treating atopic dermatitis. In numerous trials, tacrolimus ointment 0.03–0.3% has shown to be effective in reducing the symptoms and severity of atopic dermatitis in adults and the paediatric population.
Tacrolimus A Further Update of its Use in the Management of Organ Transplantation
Lesley J. Scott, Kate McKeage, Susan J. Keam & Greg L Plosker
, Drugs, Volume 63, pages 1247–1297, (2003)
Notably, the lower incidence of rejection episodes after renal transplantation in tacrolimus recipients was reflected in improved cost effectiveness. In bone marrow transplant (BMT) recipients, the incidence of tacrolimus grade II–IV graft-versus-host disease was significantly lower with tacrolimus than cyclosporin treatment.
Mechanisms of Clinically Relevant Drug Interactions Associated with Tacrolimus
Uwe Christians, Wolfgang Jacobsen, Leslie Z. Benet & Alfonso Lampen
, Clinical Pharmacokinetics, Volume 41, pages 813–851, (2002)
Interaction of other drugs with P-glycoprotein may change tacrolimus tissue distribution and modify its toxicity and immunosuppressive activity. There is evidence that ethnic and gender differences exist for tacrolimus drug interactions.
