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What is the Hydroxychloroquine sulfate ?
Hydroxychloroquine sulfate is White cyrstalline solid, while it's Molecular Formula is C18H26ClN3O*H2O4S. Hydroxychloroquine sulfate, an antimalarial drug, is also used to treat autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. It can regulate the function of the immune system and reduce inflammatory responses. Hydroxychloroquine sulfate works by affecting certain biological processes within cells. During use, some side effects may occur, such as gastrointestinal discomfort and vision problems. Hydroxychloroquine sulfate is generally produced through chemical synthesis.
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| Reply to Gautret et al: hydroxychloroquine sulfate and azithromycin for COVID-19: what is the evidence and what are the risks? |
The severity of COVID-19 has resulted in a global rush to find the right antiviral treatment to conquer the pandemic and to treat patients. This requires reliable studies to support treatment. In a recently published study by Gautret et al. the authors concluded that hydroxychloroquine monotherapy and hydroxychloroquine in combination with azithromycin reduced viral load. However, this trial has several major methodological issues, including the design, outcome measure and the statistical analyses. In this paper we discuss the background, clinical evidence, pharmacology and methodological issues related to this clinical trial. We understand the rush to release results, however in case conclusions are far reaching the evidence needs to be robust.
, International Journal of Antimicrobial Agents Volume 56, Issue 1, July 2020, 106056
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| Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus |
Systemic lupus erythematosus (SLE) is a clinically diverse, complex autoimmune disease which may present with coincident onset of many criteria or slow, gradual symptom accrual. Early intervention has been postulated to delay or prevent the development of more serious sequelae. One option for treatment in this setting is hydroxychloroquine. Using 130 US military personnel who later met ACR SLE criteria, a retrospective study of onset, development and progression of SLE with and without pre-classification hydroxychloroquine (n = 26) use was performed. Patients treated with hydroxychloroquine prior to diagnosis had a longer (Wilcoxon signed rank test, P = 0.018) time between the onset of the first clinical symptom and SLE classification (median: 1.08 versus 0.29 years). Patients treated with prednisone before diagnosis also more slowly satisfied the classification criteria (Wilcoxon signed rank test, P = 0.011).
, Lupus, 2007, Volume 16, Issue 6
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