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What is the Imidazole ?
Imidazole is white to off white crystals, while it's Molecular Formula is C3H4N2. Imidazole is an organic compound. It is an important structural unit of many drugs and bioactive molecules. Imidazole is weakly alkaline and can participate in a variety of chemical reactions. In the field of medicine, it is often used to synthesize antifungal drugs. In chemical research, it is a commonly used ligand and catalyst. Imidazole can be prepared by a variety of synthetic methods, such as through the reaction of glyoxal, formaldehyde and ammonia.
| Article |
Abstract |
| Naturally Occurring and Synthetic Imidazoles: Their Chemistry and Their Biological Activities |
Imidazoles are an important class of heterocycles and include many substances of both biological and chemical interest. They are part of a large number of highly significant biomolecules such as the essential amino acid histidine and related compounds, biotin, and the imidazole alkaloids. Insertion of the imidazole nucleus is an important synthetic strategy in drug discovery.
, Current Medicinal Chemistry, Volume 13, Number 1, 2006, pp. 1-23(23)
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| Synthesis and therapeutic potential of imidazole containing compounds |
Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. It is also known as 1, 3-diazole. For an acid imidazole, the dissociation constant is 14.5, which makes it less acidic than phenol, imides, and carboxylic acid except for alcohols (which is less acidic than imidazole). For a basic imidazole, the dissociation constant (pKa) is approximately 7 (which makes imidazole 60 times more basic than pyridine). The acidic proton is present on the first nitrogen atom of the imidazole ring.
, BMC Chemistry, Volume 15, article number 12, (2021)
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